| PICO/Mini-CAT | Question |
| 1 | In adults hospitalized with psychotic disorders, does initiation of LAI antipsychotics compared with PO antipsychotics reduce relapse rates and rehospitalization after discharge? |
| 2 | In patients with autism spectrum disorder and sensory-triggered agitation, does access to an iPad/tablet compared to standard care reduce episodes of agitation, self-injurious behavior, and the use of medications and restraints? |
| 3 | In adults with treatment-resistant schizophrenia (TRS), does clozapine monotherapy compared with antipsychotic polypharmacy improve positive symptom control and reduce relapse or rehospitalization rates? |
