| PICO/Mini-CAT | Question |
| 1 | In adults presenting to ED w/ suspected acute appendicitis, does the addition of POCUS to standard clinical evaluation (history, physical exam, labs) improve the accuracy of diagnosis compared to clinical evaluation alone? |
| 2 | In adults presenting to the ED w/ acute non-radiating MSK pain, does IM ketorolac compared with PO NSAIDs or PO acetaminophen lead to better short-term pain relief and fewer adverse effects? |
| 3 | In adults presenting to ED w/ acute acetaminophen overdose, does IV N-acetylcysteine compared to PO N-acetylcysteine more effectively prevent hepatotoxicity? |
